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AMTB hydrochloride

CAS No. 926023-82-7

AMTB hydrochloride ( AMTB HCl )

Catalog No. M27139 CAS No. 926023-82-7

AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AMTB hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases.
  • Description
    AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat.(In Vivo):For rats, AMTB (10 mg/kg) significantly attenuated reflex responses to noxious urinary bladder distension (UBD) to 5.42 and 56.51% of the maximal visceromotor reflex (VMR) response and pressor response, respectively. The ID50 value on VMR response was 2.42 +/- 0.46 mg/kg .
  • Synonyms
    AMTB HCl
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    PPARδ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    926023-82-7
  • Formula Weight
    431.0
  • Molecular Formula
    C23H27ClN2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Michael Downes, et al. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof. Patent WO2017062468A1.
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